Olaparib is a kind of novel poly ADP-ribose polymerase (PARP) inhibitors, including PARP1, PARP2, and PARP3. PARP mediates a DNA-repair mechanism which plays a important role in DNA damage repair and apoptosis, so olaparib specifically targets on the DNA repair mechanism of the targeting cell DNA repair and take effects by attacking the critical vulnerabilities of cancer cells carrying mutations in BRCA1 and BRCA2. Owing to this mechanism, it can be used for the maintenance therapy of patients of severe recurrent ovarian cancer who has breast cancer susceptibility gene (BRCA) mutation as well as being sensitive to platinum drug. Scientists from Harvard Medical School Dana-Farber Cancer Institute have found that the target site of olaparib is the polymerase Q (POLQ, also known POLθ). Those scientists found that a large number of patients of ovarian cancer has the genetic deficiency in the homologous recombination (homologous recombination, HR) repair pathway and dramatic up-regulated expression of POLQ greatly. Since HR is an important repair pathway for repairing broken DNA, they speculated that the major function of POLQ is to compensate for the lack of HR and participate in DNA repair. The experiment has demonstrated that, in normal HR cells, knockout of POLQ would make HR activity increase significantly; while in HR deficient cells, the knockout of POLQ leads to cell death. POLQ contains RAD51 binding domain which can block the process of RAD51-mediated DNA repair. Related research has been published in the February 12, 2015 Nature journal with Raphael Ceccaldi being the first author of this research. Studies have revealed that about 10% of ovarian cancer patients and 5% of breast cancer patients contain BRCA1 or BRCA2 mutations. Both BRCA1 and BRCA2 belong to tumor suppressor genes as the major components of HR repair pathway. Their mutation suggests the loss of function for the HR repair pathway. In the cancer model of BRCA1 or BRCA2 mutations, blocking the important component for repairing single-strand DNA breaks--PARP can kill the mutated cancer cells. Put the BRCA-deficient mice with POLQ deficient mice for hybridization will cause the death of mouse embryos shortly after birth, which means that the coexistence of two repair pathway deficiency will cause embryonic lethality. These above findings suggest that olaparib, a kind of novel oral PARP inhibitor which is able to kill BRCA deficient cells, may be the effective drug for treating cancer patients who carry such mutations. Previously, researcher s knowledge of the BRCA mutation hasn t influenced patients choice of treatment on either ovarian cancer or breast cancer. However, after the study, which means that olaparib can be used for the targeted therapy of cancer patients who carries BRCA1 or BRCA2 gene mutations with the therapeutic target site being the genetic deficiency of cancer cell genetic defect rather than a target organ. In ovarian and breast cancer cells, BRCA mutations are the first heavy blow to the survivability of cell because it increases their susceptibility to DNA damage. Through targeting the PARP-controlled adjuvant repair pathways, olaparib and its similar drugs achieve the second heavy blow to the survivability of cell. With the disorders of both of the two repairmen signaling pathways, the accumulation of DNA damage exert the third heavy blow to the cells.
White to light yellow powder
Loss on drying
Sample correspond to that of standard preparation
Famouschem Technology(Shanghai) Co., Ltd. is established in 2012 and located in Shanghai---the economic center of China. We have one workshop with production capacity of 5000 tons per year, and one research and test center which is located in Jiangsu province. In Shanghai office, there still has a professional sales team whose average exporting experience is over 4 years. Our customers are from all over the world, such as East and South-East Asia, North America, Europe and Australia. Our business philosophy is to provide high quality products, great service and competitive price for customers. Your satisfaction is our perseverant pursuit. Welcome to our company when you are convenient.
Famouschem has its own unique experimentatal plateform, and is constructing a standard CMC R&D center. Meanwhile,we have established close cooperation with GMP and FDA cGMP factories.Famouschem can provide you with products and technical support that meet the requirements of new drug research and development at all stages.
With excellent quality products and good service, our products have been widely used all around the world.
Famouschem QC department insists on strict management &control in the supplier evaluation,raw material purchasing, production controller to product testing and releasing.
The QC department equipped with a lot of professional equipment,include Agilent HPLC(with DAD&ELSD detectors),polarimeter,Melting Point meter,water analyzer,etc.
MS&NMR data can also be tested by our long-term partners.
Packing & Delivery
For products with liquid form, according to the quantity you need and your requirement of package, they can be packed by 1 kg/bottle, 5 kg/drum; 25 kg/drum; 200 kg/drum or IBC drum, etc.
For products with solid form, according to the quantity you need and your requirement of package, they can be packed by 1 kg/bag; 25 kg/bag; 50 kg/bag; 25 kg/drum, ton bag, etc.
For small quantities, we usually choose DHL, FedEx, TNT, EMS, UPS or other special transportation lines. Besides, air transport also is normal and available.
There are a lot of payment ways for your choice, such as T/T, Paypal, Credit card, Alibaba trade insurance and Western Union.
Besides, you can also pay RMB via Alipay or other channels.
Q1: Are you a manufacturer or trading company? Re: We are one company integrated industry and trade. No matter the products we manufacture or trade, high quality products and competitive price always will be provided for you.
Q2: May I get one sample before placing order? Re: Yes, we'd like to provide sample for you. For those normal products, you just need to bear the freight; for those high value products, you just need to freight and a little product cost. When we both cooperate for some times or when you are our VIP customer, free sample will be offered when you need.
Q3: Which payment is available for your company? Re: In order to prompt our cooperation, there are some payment methods for your choice. T/T(USD), Western union, Paypal, Credit card, Alipay or Alibaba trade insurance all is ok. You can choose the one which is convenient for you.
Q4: How and when can I get my goods after payment? Re: For small quantity products, they will be delivered to you by international courier(DHL, FedEx, T/T, EMS, etc.) or by air. Usually it will cost 2-5 days that you can get the goods after delivery. For large quantity products, shipment is better. It will cost days to weeks to come to your destination port, which depends on where the port is.
Q5: Is there any possible to use my appointed label or package? Re: Sure. If needed, we'd like to use label or package according to your requirement.
Q6: How can you guarantee the goods you offer is qualified? Re: We always believe honesty and responsibility are basis of one company, so whatever products we provide for you all are high qualified. If the goods can't come to the quality we promise, you can ask for refund.